DE602004032248D1 - Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren - Google Patents
Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahrenInfo
- Publication number
- DE602004032248D1 DE602004032248D1 DE602004032248T DE602004032248T DE602004032248D1 DE 602004032248 D1 DE602004032248 D1 DE 602004032248D1 DE 602004032248 T DE602004032248 T DE 602004032248T DE 602004032248 T DE602004032248 T DE 602004032248T DE 602004032248 D1 DE602004032248 D1 DE 602004032248D1
- Authority
- DE
- Germany
- Prior art keywords
- neural stem
- stem cells
- proliferation
- promoting
- stem cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000001178 neural stem cell Anatomy 0.000 title abstract 12
- 238000000034 method Methods 0.000 title abstract 7
- 230000035755 proliferation Effects 0.000 title abstract 5
- 230000004083 survival effect Effects 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 238000012216 screening Methods 0.000 title abstract 2
- 230000001737 promoting effect Effects 0.000 title 2
- 210000002241 neurite Anatomy 0.000 title 1
- 238000010998 test method Methods 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 abstract 3
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 102000000795 Galectin 1 Human genes 0.000 abstract 1
- 108010001498 Galectin 1 Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000012911 assay medium Substances 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/59—Lectins
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003317379 | 2003-09-09 | ||
PCT/JP2004/013043 WO2005026343A1 (ja) | 2003-09-09 | 2004-09-08 | 神経幹細胞の生存及び/又は増殖及び神経突起伸張を促進する方法並びに促進剤、神経幹細胞を含む医薬組成物、検定方法、スクリーニング方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004032248D1 true DE602004032248D1 (de) | 2011-05-26 |
Family
ID=34308479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004032248T Active DE602004032248D1 (de) | 2003-09-09 | 2004-09-08 | Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren |
Country Status (6)
Country | Link |
---|---|
US (1) | US7785596B2 (de) |
EP (1) | EP1674566B1 (de) |
JP (2) | JP5099288B2 (de) |
AT (1) | ATE505539T1 (de) |
DE (1) | DE602004032248D1 (de) |
WO (1) | WO2005026343A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4997432B2 (ja) * | 2006-02-10 | 2012-08-08 | 学校法人慶應義塾 | 神経幹細胞の増殖抑制剤 |
JP4925262B2 (ja) * | 2006-04-05 | 2012-04-25 | 学校法人慶應義塾 | シグナル伝達系活性化剤 |
US20100330602A1 (en) * | 2006-09-19 | 2010-12-30 | Emory University | Use of Soluble Galectin-3 (Gal-3) for Cancer Treatment |
US9387226B2 (en) | 2006-11-30 | 2016-07-12 | Medipost Co., Ltd | Neural cell proliferation induced through the culture of neural cells with umbilical cord blood-derived mesenchymal stem cells |
AU2008206884B2 (en) * | 2007-01-18 | 2012-07-05 | Glykos Finland Oy | Novel methods and reagents directed to production of cells |
US20100120142A1 (en) | 2008-07-11 | 2010-05-13 | Suomen Punainen Risti Veripalvelu | Culture of human embryonic cells |
AU2009267964A1 (en) * | 2008-07-11 | 2010-01-14 | Glykos Finland Oy | Culture of cells |
KR20100054711A (ko) | 2008-11-14 | 2010-05-25 | 메디포스트(주) | 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물 |
JP2012029684A (ja) * | 2010-06-30 | 2012-02-16 | Cell Aid Kenkyusho:Kk | 細胞の製造方法 |
US9694049B2 (en) * | 2011-08-11 | 2017-07-04 | Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Unitversity Of Nevada, Reno | Methods for treating muscular dystrophy |
BR112017022715A2 (pt) | 2015-04-21 | 2018-07-17 | Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet | variante do polipeptídeo gal-1, ácido nucleico, composição farmacêutica, método para modular uma resposta imunológica e método para tratamento de um sujeito |
JP2019537432A (ja) | 2016-10-04 | 2019-12-26 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 標的化エフェクタータンパク質およびその使用 |
US11407797B2 (en) | 2017-10-11 | 2022-08-09 | University Of Florida Research Foundation, Incorporated | Modified gal-1 proteins and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
US5968829A (en) * | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
WO2000006724A1 (fr) | 1998-07-31 | 2000-02-10 | Kirin Beer Kabushiki Kaisha | Medicaments permettant de soigner la neuropathie contenant de la galectine-1 ou ses derives comme substance active |
US6436389B1 (en) * | 1998-12-11 | 2002-08-20 | The Salk Institute For Biological Studies | Stimulation of cell proliferation by glycosylated cystatin C |
CA2409703A1 (en) | 2000-05-16 | 2001-11-22 | Shin-Ichi Nishikawa | Novel differentiation inducing process of embryonic stem cell to ectodermal cell and its use |
WO2002086082A2 (en) * | 2001-04-20 | 2002-10-31 | Children's Hospital Of Orange County | Isolation of neural stem cells using gangliosides and other surface markers |
JP2002325571A (ja) | 2001-04-27 | 2002-11-12 | Purotekku:Kk | 網膜の分化誘導方法 |
JP3566941B2 (ja) | 2001-05-31 | 2004-09-15 | 独立行政法人 科学技術振興機構 | MusashiによるNumbタンパク質発現抑制剤 |
CN1458273A (zh) * | 2002-01-16 | 2003-11-26 | 中国医学科学院中国协和医科大学血液学研究所 | 人胎儿背根神经节干细胞的分离、制备及应用 |
US8043853B2 (en) * | 2002-08-14 | 2011-10-25 | The Regents Of The University Of Michigan | Postnatal gut neural crest stem cells |
CA2494450A1 (en) * | 2002-08-27 | 2004-03-11 | Stemcells, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
-
2004
- 2004-09-08 JP JP2005513873A patent/JP5099288B2/ja not_active Expired - Fee Related
- 2004-09-08 EP EP04787726A patent/EP1674566B1/de not_active Not-in-force
- 2004-09-08 US US10/571,277 patent/US7785596B2/en not_active Expired - Fee Related
- 2004-09-08 DE DE602004032248T patent/DE602004032248D1/de active Active
- 2004-09-08 AT AT04787726T patent/ATE505539T1/de not_active IP Right Cessation
- 2004-09-08 WO PCT/JP2004/013043 patent/WO2005026343A1/ja active Application Filing
-
2012
- 2012-01-11 JP JP2012003320A patent/JP2012077092A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1674566A1 (de) | 2006-06-28 |
ATE505539T1 (de) | 2011-04-15 |
EP1674566A4 (de) | 2007-01-17 |
EP1674566B1 (de) | 2011-04-13 |
JP2012077092A (ja) | 2012-04-19 |
JP5099288B2 (ja) | 2012-12-19 |
US20070098701A1 (en) | 2007-05-03 |
US7785596B2 (en) | 2010-08-31 |
JPWO2005026343A1 (ja) | 2007-11-08 |
WO2005026343A1 (ja) | 2005-03-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602004032248D1 (de) | Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren | |
Ohlendieck et al. | Nitrogen fixation by diazotrophic cyanobacteria in the Baltic Sea and transfer of the newly fixed nitrogen to picoplankton organisms | |
Huang et al. | Alkaline phosphatase activity and utilization of dissolved organic phosphorus by algae in subtropical coastal waters | |
ATE480615T1 (de) | Verfahren zur proliferation von stammzellen | |
Arakaki et al. | Involvement of reactive oxygen species in osteoblastic differentiation of MC3T3-E1 cells accompanied by mitochondrial morphological dynamics | |
ATE510004T1 (de) | In-vitro-techniken zur verwendung mit stammzellen | |
BRPI0612967B8 (pt) | método para a determinação in vitro da atividade de trombina em uma amostra biológica e kit | |
BR112012014925A2 (pt) | compostos promotores de replicação de células beta e métodos de uso dos mesmos | |
RU2010105690A (ru) | Ифференцировка эмбриональных стволовых клеток человека | |
IL188874A0 (en) | APOPTOSIS SENSIVITY TO AP02L/TRAIL BY TESTING FOR GalNac -T14 EXPRESSION IN CELLS/TISSUES | |
WO2005105984A3 (en) | Culture conditions and growth factors affecting fate determination, self-renewal and expansion of mouse spermatogonial stem cells | |
GEP20094715B (en) | Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures | |
ATE489622T1 (de) | Verfahren zur beurteilung der malignität einer säuger-krebszelle | |
TW200736399A (en) | Expansion and differentiation of neural stem cells under low oxygen conditions | |
Oleksy et al. | Nutrients and warming alter mountain lake benthic algal structure and function | |
DE602007013695D1 (de) | Leuchtende stammzellen und ihre verwendung | |
Tulonen et al. | Factors controlling production of phytoplankton and bacteria under ice in a humic, boreal lake | |
EP1687413A4 (de) | Verfahren zur differenzierung einer mesenchym-stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit | |
Imai et al. | Oral malodorous compound inhibits osteoblast proliferation | |
ATE415484T1 (de) | Verfahren und zusammensetzungen zur charakterisierung eines redox-reagenz-system enzyms | |
Vannini et al. | Identification of in vitro HSC fate regulators by differential lipid raft clustering | |
ZA200807766B (en) | Inhibition of GASC1 | |
EP1670902A4 (de) | Verfahren und zusammensetzung zur verbesserung der embryoentwicklung in vitro durch ergänzen des kulturmediums mit prostaglandin oder einem prostaglandinanalogen | |
TWI613446B (zh) | 使用脂肪組織衍生之幹細胞進行的神經生成篩選方法和系統 | |
Bianchi et al. | Microbial activities at the benthic boundary layer in the Aegean Sea |