DE602004032248D1 - Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren - Google Patents

Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren

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Publication number
DE602004032248D1
DE602004032248D1 DE602004032248T DE602004032248T DE602004032248D1 DE 602004032248 D1 DE602004032248 D1 DE 602004032248D1 DE 602004032248 T DE602004032248 T DE 602004032248T DE 602004032248 T DE602004032248 T DE 602004032248T DE 602004032248 D1 DE602004032248 D1 DE 602004032248D1
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Germany
Prior art keywords
neural stem
stem cells
proliferation
promoting
stem cell
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Active
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DE602004032248T
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English (en)
Inventor
Hideyuki Okano
James Okano
Masanori Sakaguchi
H Mizusawa
S Ishibashi
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Keio University
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Keio University
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Publication of DE602004032248D1 publication Critical patent/DE602004032248D1/de
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/59Lectins
DE602004032248T 2003-09-09 2004-09-08 Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren Active DE602004032248D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003317379 2003-09-09
PCT/JP2004/013043 WO2005026343A1 (ja) 2003-09-09 2004-09-08 神経幹細胞の生存及び/又は増殖及び神経突起伸張を促進する方法並びに促進剤、神経幹細胞を含む医薬組成物、検定方法、スクリーニング方法

Publications (1)

Publication Number Publication Date
DE602004032248D1 true DE602004032248D1 (de) 2011-05-26

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DE602004032248T Active DE602004032248D1 (de) 2003-09-09 2004-09-08 Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren

Country Status (6)

Country Link
US (1) US7785596B2 (de)
EP (1) EP1674566B1 (de)
JP (2) JP5099288B2 (de)
AT (1) ATE505539T1 (de)
DE (1) DE602004032248D1 (de)
WO (1) WO2005026343A1 (de)

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JP4997432B2 (ja) * 2006-02-10 2012-08-08 学校法人慶應義塾 神経幹細胞の増殖抑制剤
JP4925262B2 (ja) * 2006-04-05 2012-04-25 学校法人慶應義塾 シグナル伝達系活性化剤
US20100330602A1 (en) * 2006-09-19 2010-12-30 Emory University Use of Soluble Galectin-3 (Gal-3) for Cancer Treatment
US9387226B2 (en) 2006-11-30 2016-07-12 Medipost Co., Ltd Neural cell proliferation induced through the culture of neural cells with umbilical cord blood-derived mesenchymal stem cells
AU2008206884B2 (en) * 2007-01-18 2012-07-05 Glykos Finland Oy Novel methods and reagents directed to production of cells
US20100120142A1 (en) 2008-07-11 2010-05-13 Suomen Punainen Risti Veripalvelu Culture of human embryonic cells
AU2009267964A1 (en) * 2008-07-11 2010-01-14 Glykos Finland Oy Culture of cells
KR20100054711A (ko) 2008-11-14 2010-05-25 메디포스트(주) 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물
JP2012029684A (ja) * 2010-06-30 2012-02-16 Cell Aid Kenkyusho:Kk 細胞の製造方法
US9694049B2 (en) * 2011-08-11 2017-07-04 Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Unitversity Of Nevada, Reno Methods for treating muscular dystrophy
BR112017022715A2 (pt) 2015-04-21 2018-07-17 Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet variante do polipeptídeo gal-1, ácido nucleico, composição farmacêutica, método para modular uma resposta imunológica e método para tratamento de um sujeito
JP2019537432A (ja) 2016-10-04 2019-12-26 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 標的化エフェクタータンパク質およびその使用
US11407797B2 (en) 2017-10-11 2022-08-09 University Of Florida Research Foundation, Incorporated Modified gal-1 proteins and uses thereof

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
WO2000006724A1 (fr) 1998-07-31 2000-02-10 Kirin Beer Kabushiki Kaisha Medicaments permettant de soigner la neuropathie contenant de la galectine-1 ou ses derives comme substance active
US6436389B1 (en) * 1998-12-11 2002-08-20 The Salk Institute For Biological Studies Stimulation of cell proliferation by glycosylated cystatin C
CA2409703A1 (en) 2000-05-16 2001-11-22 Shin-Ichi Nishikawa Novel differentiation inducing process of embryonic stem cell to ectodermal cell and its use
WO2002086082A2 (en) * 2001-04-20 2002-10-31 Children's Hospital Of Orange County Isolation of neural stem cells using gangliosides and other surface markers
JP2002325571A (ja) 2001-04-27 2002-11-12 Purotekku:Kk 網膜の分化誘導方法
JP3566941B2 (ja) 2001-05-31 2004-09-15 独立行政法人 科学技術振興機構 MusashiによるNumbタンパク質発現抑制剤
CN1458273A (zh) * 2002-01-16 2003-11-26 中国医学科学院中国协和医科大学血液学研究所 人胎儿背根神经节干细胞的分离、制备及应用
US8043853B2 (en) * 2002-08-14 2011-10-25 The Regents Of The University Of Michigan Postnatal gut neural crest stem cells
CA2494450A1 (en) * 2002-08-27 2004-03-11 Stemcells, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations

Also Published As

Publication number Publication date
EP1674566A1 (de) 2006-06-28
ATE505539T1 (de) 2011-04-15
EP1674566A4 (de) 2007-01-17
EP1674566B1 (de) 2011-04-13
JP2012077092A (ja) 2012-04-19
JP5099288B2 (ja) 2012-12-19
US20070098701A1 (en) 2007-05-03
US7785596B2 (en) 2010-08-31
JPWO2005026343A1 (ja) 2007-11-08
WO2005026343A1 (ja) 2005-03-24

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