WO2000033791A3 - Co-factors for trophic factors, and methods of use thereof - Google Patents

Co-factors for trophic factors, and methods of use thereof Download PDF

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Publication number
WO2000033791A3
WO2000033791A3 PCT/US1999/029533 US9929533W WO0033791A3 WO 2000033791 A3 WO2000033791 A3 WO 2000033791A3 US 9929533 W US9929533 W US 9929533W WO 0033791 A3 WO0033791 A3 WO 0033791A3
Authority
WO
WIPO (PCT)
Prior art keywords
factor
factors
trophic
trophic factors
ccg
Prior art date
Application number
PCT/US1999/029533
Other languages
French (fr)
Other versions
WO2000033791A2 (en
Inventor
Fred Harrison Gage
Philippe J Taupin
Jasodhara Ray
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Priority to EP99966171A priority Critical patent/EP1147126A4/en
Priority to AU21780/00A priority patent/AU2178000A/en
Priority to CA002354378A priority patent/CA2354378A1/en
Publication of WO2000033791A2 publication Critical patent/WO2000033791A2/en
Publication of WO2000033791A3 publication Critical patent/WO2000033791A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin

Abstract

The present invention is based on the discovery and isolation of a co-factor for trophic factors. It has been discovered that trophic factors require a co-factor to stimulate and/or potentiate the trophic factor activity and/or specificity. This was clearly identified in low density cells where trophic factors are unable, or at best, at minimal levels, able to proliferate undifferentiated cells without a co-factor. In a particular embodiment of the present invention, there is provided a composition comprising glycosylated cystatin C (CCg), an FGF co-factor that stimulates proliferation of neural and fibroblast associated undifferentiated cells. The N-glycosylation of cystatin C is required for its activity. Moreover, CCg acts in cooperation with basic fibroblast growth factor (FGF-2) to induce neural progenitor cell proliferation.
PCT/US1999/029533 1998-12-11 1999-12-13 Co-factors for trophic factors, and methods of use thereof WO2000033791A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99966171A EP1147126A4 (en) 1998-12-11 1999-12-13 Co-factors for trophic factors, and methods of use thereof
AU21780/00A AU2178000A (en) 1998-12-11 1999-12-13 Co-factors for trophic factors, and methods of use thereof
CA002354378A CA2354378A1 (en) 1998-12-11 1999-12-13 Co-factors for trophic factors, and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21034498A 1998-12-11 1998-12-11
US09/210,344 1998-12-11

Publications (2)

Publication Number Publication Date
WO2000033791A2 WO2000033791A2 (en) 2000-06-15
WO2000033791A3 true WO2000033791A3 (en) 2000-08-17

Family

ID=22782537

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/029533 WO2000033791A2 (en) 1998-12-11 1999-12-13 Co-factors for trophic factors, and methods of use thereof

Country Status (5)

Country Link
US (2) US6436389B1 (en)
EP (1) EP1147126A4 (en)
AU (1) AU2178000A (en)
CA (1) CA2354378A1 (en)
WO (1) WO2000033791A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6565181B2 (en) * 1997-07-12 2003-05-20 Silverbrook Research Pty Ltd Printing cartridge with switch array identification
US20050180945A1 (en) * 2002-05-21 2005-08-18 Chaikof Elliot L. Multivalent polymers with chan-terminating binding groups
WO2005026343A1 (en) * 2003-09-09 2005-03-24 Keio University Method of promoting subsistence and/or proliferation of neural stem cell and promoting extension of neurite, promoter therefor, pharmaceutical composition containing neural stem cell, method of assay and method of screening
CN1562050A (en) * 2004-03-24 2005-01-12 中国海洋大学 Use of oligose alginate in anti-dementia and anti-diabetes
US20060040321A1 (en) * 2004-03-31 2006-02-23 The Salk Institute For Biological Studies Orphan receptor TLX and uses therefor
ES2318915B1 (en) * 2004-12-29 2010-02-16 Universidad De Salamanca USE OF FGF-2 IN OLIGODENDROCIT PRECURSOR CELLS.
US20060183712A1 (en) * 2005-02-17 2006-08-17 The Texas A&M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
PL1952154T3 (en) * 2005-11-24 2010-10-29 Gentian As Turbidimetric immunoassay for assessing human cystatin c
EP2147312B1 (en) * 2007-05-21 2012-08-15 Gentian AS Turbidimetric immunoassay for assessing human cystatin c
WO2010060928A2 (en) * 2008-11-26 2010-06-03 Projech Science To Technology, S.L. Compositions for the treatment of ischemic tissue damage
CN102095872A (en) * 2010-11-08 2011-06-15 武汉生之源生物科技有限公司 Enhanced cystatin C assay kit based on large-particle-size latex
CN111171215B (en) * 2020-02-25 2021-06-01 北京汉莫克化学技术有限公司 Environment-friendly agricultural dispersant and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0511816A2 (en) * 1991-04-27 1992-11-04 Sumitomo Pharmaceuticals Company, Limited Neurotrophic peptide derivative

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SI8510058A8 (en) * 1985-01-16 1996-04-30 Inst Jozef Stefan P O Process for insulation of poultry egg's cystatine from egg-white
DK260987D0 (en) * 1987-05-22 1987-05-22 Nordisk Gentofte PROCEDURE FOR PREPARING A HUMAN PROTEIN AND THE DNA SEQUENCE FOR USE IN EXERCISING THE PROCEDURE
DE3724581A1 (en) * 1987-07-24 1989-02-02 Gruenenthal Gmbh DNA SEQUENCES COATING FOR PROTEINS WITH THE BIOLOGICAL PROPERTIES OF CYSTATINE C, PREPARATION OF THESE DNA SEQUENCES, EXPRESSION OF CYSTATINE C, AND PHARMACEUTICAL PREPARATIONS CONTAINING THEREOF
US5851832A (en) * 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5980885A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. Growth factor-induced proliferation of neural precursor cells in vivo
US5766948A (en) * 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
US5733893A (en) * 1995-03-15 1998-03-31 Washington University Method of identifying molecules that regulate FGF activity
AU5144299A (en) * 1998-08-05 2000-02-28 University Of British Columbia, The Production and use of modified cystatins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0511816A2 (en) * 1991-04-27 1992-11-04 Sumitomo Pharmaceuticals Company, Limited Neurotrophic peptide derivative

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COLE ET AL.: "The cDNA structure and expression analysis of the genes for the cysteine proteinase inhibitor cystatin C and beta2-microglobulin in rat brain", EUR. J. BIOCHEM.,, vol. 186, 1989, pages 35 - 42, XP002926754 *
RAY ET AL.: "A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for tits mitogenic actitity on neural progenitor cells", PROC. NATL. ACAD. SCI. USA,, vol. 94, June 1997 (1997-06-01), pages 7047 - 7052, XP002926755 *
YASUKURA ET AL.: "Purification and characterization of neurotrophic factor for retinal cholinergic neurons derived from cultured hippocampal neurons", JPN. J. PHARMACOL.,, vol. 65, 1994, pages 153 - 162, XP002926756 *

Also Published As

Publication number Publication date
US6436389B1 (en) 2002-08-20
EP1147126A2 (en) 2001-10-24
AU2178000A (en) 2000-06-26
US20030022261A1 (en) 2003-01-30
WO2000033791A2 (en) 2000-06-15
CA2354378A1 (en) 2000-06-15
EP1147126A4 (en) 2003-07-09

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