WO2004011632A3 - Oligodendrocyte production from multipotent neural stem cells - Google Patents
Oligodendrocyte production from multipotent neural stem cells Download PDFInfo
- Publication number
- WO2004011632A3 WO2004011632A3 PCT/CA2003/001151 CA0301151W WO2004011632A3 WO 2004011632 A3 WO2004011632 A3 WO 2004011632A3 CA 0301151 W CA0301151 W CA 0301151W WO 2004011632 A3 WO2004011632 A3 WO 2004011632A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem cells
- neural stem
- multipotent neural
- oligodendrocyte
- oligodendrocyte production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/202—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2033—IL-5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004523706A JP4783013B2 (en) | 2002-07-30 | 2003-07-30 | Oligodendrocyte production from pluripotent neural stem cells |
CA002492542A CA2492542A1 (en) | 2002-07-30 | 2003-07-30 | Oligodendrocyte production from multipotent neural stem cells |
US10/523,253 US7704737B2 (en) | 2002-07-30 | 2003-07-30 | Oligodendrocyte production from multipotent neural stem cells |
AU2003250697A AU2003250697B2 (en) | 2002-07-30 | 2003-07-30 | Oligodendrocyte production from multipotent neural stem cells |
EP03771036A EP1549740A2 (en) | 2002-07-30 | 2003-07-30 | Oligodendrocyte production from multipotent neural stem cells |
AU2008203234A AU2008203234A1 (en) | 2002-07-30 | 2008-07-21 | Oligodendrocyte production from multipotent neural stem cells |
US12/698,757 US20100135968A1 (en) | 2002-07-30 | 2010-02-02 | Oligodendrocyte Production From Multipotent Neural Stem Cells |
US13/424,065 US20120189575A1 (en) | 2002-07-30 | 2012-03-19 | Oligodendrocyte Production from Multipotent Neural Stem Cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39919202P | 2002-07-30 | 2002-07-30 | |
US60/399,192 | 2002-07-30 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/698,757 Division US20100135968A1 (en) | 2002-07-30 | 2010-02-02 | Oligodendrocyte Production From Multipotent Neural Stem Cells |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004011632A2 WO2004011632A2 (en) | 2004-02-05 |
WO2004011632A3 true WO2004011632A3 (en) | 2004-04-15 |
Family
ID=31188551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2003/001151 WO2004011632A2 (en) | 2002-07-30 | 2003-07-30 | Oligodendrocyte production from multipotent neural stem cells |
Country Status (6)
Country | Link |
---|---|
US (3) | US7704737B2 (en) |
EP (2) | EP2095823A1 (en) |
JP (1) | JP4783013B2 (en) |
AU (2) | AU2003250697B2 (en) |
CA (1) | CA2492542A1 (en) |
WO (1) | WO2004011632A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8435949B2 (en) | 2004-02-13 | 2013-05-07 | Stem Cell Therapeutics Corp. | Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7838292B1 (en) | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
JP3984959B2 (en) * | 2002-03-27 | 2007-10-03 | 株式会社Gbs研究所 | Method for inducing proliferation of neural stem cells |
US20040141947A1 (en) * | 2002-10-16 | 2004-07-22 | Hunter Samuel F. | Method for treatment of demyelinating central nervous system disease |
US7695723B2 (en) * | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
WO2007036033A1 (en) * | 2005-09-27 | 2007-04-05 | Stem Cell Therapeutics Corp. | Oligodendrocyte precursor cell proliferation regulated by prolactin |
US9795652B2 (en) * | 2010-02-25 | 2017-10-24 | University Of South Florida | Use of endogenous antioxidant proteins in the treatment of stroke |
WO2018093681A1 (en) * | 2016-11-15 | 2018-05-24 | Neuralstem, Inc. | Multipotent neural stem cells that express platelet derived growth factor (pdgf) receptor and methods of use thereof |
Citations (2)
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WO1994010292A1 (en) * | 1992-10-28 | 1994-05-11 | Neurospheres Ltd. | Biological factors and neural stem cells |
WO1996015226A1 (en) * | 1994-11-14 | 1996-05-23 | Neurospheres Holdings Ltd. | Regulation of neural stem cell proliferation |
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CA2345497A1 (en) | 1988-10-28 | 1990-04-28 | Genentech, Inc. | Growth hormone variants and method for forming growth hormone variants |
US5128242A (en) * | 1989-06-19 | 1992-07-07 | The Administrators Of The Tulane Educational Fund | Hypothalamic polypeptides with adenylate cyclase stimulating activity |
US5198542A (en) * | 1989-06-20 | 1993-03-30 | Takeda Chemical Industries, Inc. | Dna encoding a pitvitary adenylate cyclase activating protein and use thereof |
US5506117A (en) | 1989-10-18 | 1996-04-09 | Cytokinetics, Inc. | Biochemical process for growing living cells by measuring the amount of nutrient added to the reaction medium |
US5612211A (en) * | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
EP0768090A3 (en) * | 1990-07-18 | 1997-06-18 | Takeda Chemical Industries Ltd | Polypeptides having c-AMP producing activity for the prevention of neuronal cell death |
US6429186B1 (en) * | 1991-05-10 | 2002-08-06 | Genentech, Inc. | Ligand antagonists for treatment of breast cancer |
US5980885A (en) * | 1991-07-08 | 1999-11-09 | Neurospheres Holdings Ltd. | Growth factor-induced proliferation of neural precursor cells in vivo |
US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
AU2489992A (en) | 1991-08-16 | 1993-03-16 | Chiron Corporation | Muteins of epidermal growth factor exhibiting enhanced binding at low ph |
US5623050A (en) | 1991-08-22 | 1997-04-22 | Takeda Chemical Industries, Ltd. | Stable polypeptides having c-AMP production enhancing activity and the use thereof |
PT664832E (en) * | 1992-10-16 | 2002-12-31 | Neurospheres Holdings Ltd | REMIELINIZATION USING NEURAL ESTAMINAL CELLS |
CA2175992C (en) * | 1993-11-09 | 2008-04-01 | Samuel Weiss | In situ modification and manipulation of stem cells of the central nervous system |
US6093531A (en) * | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
US20020136705A1 (en) * | 1998-06-30 | 2002-09-26 | Jonathan Dinsmore | Porcine spinal cord cells and their use in spinal cord repair |
US6242563B1 (en) * | 1998-07-20 | 2001-06-05 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Peptide analogues |
DE19917505A1 (en) * | 1999-04-17 | 2000-10-19 | Dresden Arzneimittel | Treating cytokine-mediated diseases, e.g. asthma, allergy, eczema, rheumatoid arthritis or transplant rejection, using new or known maduraphthalazine derivatives |
EP1185552A1 (en) * | 1999-06-16 | 2002-03-13 | Myelos Corporation | Retro-inverso peptides derived from interleukin-3 |
US7160724B2 (en) | 2000-03-09 | 2007-01-09 | University Of South Florida | Human cord blood as a source of neural tissue for repair of the brain and spinal cord |
DE60120682D1 (en) | 2000-04-12 | 2006-07-27 | Philadelphia Children Hospital | THERAPEUTIC USE OF MESENCHYMAL CURRENT COSTS |
US6673606B1 (en) * | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
DE10033219A1 (en) | 2000-07-07 | 2002-01-24 | Univ Heidelberg | Use of granulocyte colony stimulating factor as neuroprotective agent, for treating acute ischemia and neurodegenerative diseases |
WO2002020766A2 (en) * | 2000-09-08 | 2002-03-14 | Massachusetts Institute Of Technology | G-csf analog compositions and methods |
CA2441434A1 (en) * | 2001-03-12 | 2002-09-19 | Institute Of Gene And Brain Science | Remedies for nerve damages |
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US20040141947A1 (en) * | 2002-10-16 | 2004-07-22 | Hunter Samuel F. | Method for treatment of demyelinating central nervous system disease |
US7695723B2 (en) * | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US7785601B2 (en) * | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
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-
2003
- 2003-07-30 US US10/523,253 patent/US7704737B2/en not_active Expired - Fee Related
- 2003-07-30 WO PCT/CA2003/001151 patent/WO2004011632A2/en active Application Filing
- 2003-07-30 EP EP09005947A patent/EP2095823A1/en not_active Withdrawn
- 2003-07-30 JP JP2004523706A patent/JP4783013B2/en not_active Expired - Fee Related
- 2003-07-30 EP EP03771036A patent/EP1549740A2/en not_active Withdrawn
- 2003-07-30 AU AU2003250697A patent/AU2003250697B2/en not_active Ceased
- 2003-07-30 CA CA002492542A patent/CA2492542A1/en not_active Abandoned
-
2008
- 2008-07-21 AU AU2008203234A patent/AU2008203234A1/en not_active Abandoned
-
2010
- 2010-02-02 US US12/698,757 patent/US20100135968A1/en not_active Abandoned
-
2012
- 2012-03-19 US US13/424,065 patent/US20120189575A1/en not_active Abandoned
Patent Citations (2)
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WO1994010292A1 (en) * | 1992-10-28 | 1994-05-11 | Neurospheres Ltd. | Biological factors and neural stem cells |
WO1996015226A1 (en) * | 1994-11-14 | 1996-05-23 | Neurospheres Holdings Ltd. | Regulation of neural stem cell proliferation |
Non-Patent Citations (7)
Title |
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DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, DUBOIS T M ET AL: "GRANULOCYTE MACROPHAGE - COLONY STIMULATING FACTOR ( GM - CSF ) IS A FATE DETERMINATION AND DIFFERENTIATION FACTOR FOR NEURAL STEM CELL - GENERATED OLIGODENDROCYTE PRECURSORS ( OLPS ).", XP002267009, Database accession no. PREV200300293880 * |
GAGE F H: "Mammalian neural stem cells", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 287, no. 5457, 25 February 2000 (2000-02-25), pages 1433 - 1438, XP002220467, ISSN: 0036-8075 * |
KOHAMA I ET AL: "Transplantation of cryopreserved adult human Schwann cells enhances axonal conduction in demyelinated spinal cord.", THE JOURNAL OF NEUROSCIENCE : THE OFFICIAL JOURNAL OF THE SOCIETY FOR NEUROSCIENCE. 1 FEB 2001, vol. 21, no. 3, 1 February 2001 (2001-02-01), pages 944 - 950, XP002267008, ISSN: 1529-2401 * |
MCQUALTER J L ET AL: "Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.", THE JOURNAL OF EXPERIMENTAL MEDICINE. 1 OCT 2001, vol. 194, no. 7, 1 October 2001 (2001-10-01), pages 873 - 881, XP002267007, ISSN: 0022-1007 * |
MEHLER M F ET AL: "Cytokines regulate the cellular phenotype of developing neural lineage species.", INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE : THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR DEVELOPMENTAL NEUROSCIENCE. 1995 JUN-JUL, vol. 13, no. 3-4, June 1995 (1995-06-01), pages 213 - 240, XP002267006, ISSN: 0736-5748 * |
See also references of EP1549740A2 * |
SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 329.12 URL - http://sf * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8435949B2 (en) | 2004-02-13 | 2013-05-07 | Stem Cell Therapeutics Corp. | Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis |
Also Published As
Publication number | Publication date |
---|---|
US20100135968A1 (en) | 2010-06-03 |
JP4783013B2 (en) | 2011-09-28 |
AU2003250697A1 (en) | 2004-02-16 |
CA2492542A1 (en) | 2004-02-05 |
AU2008203234A1 (en) | 2008-08-07 |
JP2005534302A (en) | 2005-11-17 |
US20050244965A1 (en) | 2005-11-03 |
WO2004011632A2 (en) | 2004-02-05 |
US20120189575A1 (en) | 2012-07-26 |
US7704737B2 (en) | 2010-04-27 |
AU2003250697B2 (en) | 2008-05-01 |
EP2095823A1 (en) | 2009-09-02 |
EP1549740A2 (en) | 2005-07-06 |
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