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Publication numberWO2006085587 A1
Publication typeApplication
Application numberPCT/JP2006/302259
Publication date17 Aug 2006
Filing date9 Feb 2006
Priority date9 Feb 2005
Publication numberPCT/2006/302259, PCT/JP/2006/302259, PCT/JP/6/302259, PCT/JP2006/302259, PCT/JP2006302259, PCT/JP6/302259, PCT/JP6302259, WO 2006/085587 A1, WO 2006085587 A1, WO 2006085587A1, WO-A1-2006085587, WO2006/085587A1, WO2006085587 A1, WO2006085587A1
InventorsMasahiro Toda, Shigeki Ohta, Masae Yaguchi, Hideyuki Okano
ApplicantKeio University, Institute Of Gene And Brain Science
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
WO 2006085587 A1
【課題】高効率にニューロスフェアを形成するニューロスフェア形成剤及び神経障害によって障害が生じた神経機能を効率よく改善する医薬組成物を提供すること。  【解決手段】マウスCD8α陽性樹状細胞、成熟樹状細胞、Notch陽性樹状細胞を分離し、それらを単独に、あるいは複数含有するニューロスフェア形成剤または医薬組成物とする。ニューロスフェア形成剤が含有する樹状細胞を、神経幹細胞と共培養することにより、高効率にニューロスフェアを形成することができる。また、医薬組成物を神経損傷部分に投与することにより、障害が生じた神経機能を効率よく改善することができる。
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
WO2003080818A1 *27 Mar 20032 Oct 2003Institute Of Gene And Brain ScienceMethode permettant d'induire la croissance des cellules souches nerveuses
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Non-Patent Citations
1 *COLVIN B.L. ET AL.: 'Disparate ability of murine CD8alpha- and CD8alpha+ dendritic cell subsets to traverse endothelium is not determined by differential CD11b expression' IMMUNOLOGY vol. 113, no. 3, 2004, pages 328 - 337, XP003001961
2 *SCHULZ O. ET AL.: 'Cross-presentation of cell-associated antigens by CD8alpha+ dendritic cells is attributable to their ability to internalize dead cells' IMMUNOLOGY vol. 117, no. 2, 2002, pages 183 - 189, XP003001962
3 *TODA M.: 'Jujo Saibo o Mochiita Shinkei Saisei' MEDICAL SCIENCE DIGEST vol. 30, no. 11, 2004, pages 456 - 459, XP003001960
International ClassificationC12Q1/02, A61K35/28, A61P25/28, C12N15/09, A61K35/12
Cooperative ClassificationA61K35/15
European ClassificationA61K35/28, A61K35/12
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